Long lasting facilitation of the rabbit cardiac Ca2+ channel: correlation with the coupling efficiency between charge movement and pore opening

FEBS Lett. 1998 Feb 20;423(2):213-7. doi: 10.1016/s0014-5793(98)00092-1.

Abstract

Facilitation of Ca2+ entry into cells enhances Ca(2+)-activated events such as transmitter release and stimulation of second messenger systems. We have found a long lasting prepulse facilitation (up to 3-fold) of the cardiac Ca2+ channel alpha1Cbeta1b that lasts for tens of seconds without altering current kinetics. The voltage- and time-dependence of the installation of facilitation was characterized as well as the time- and use-dependence of the decay of facilitation. The degree of facilitation was correlated with the coupling efficiency between the charge movement and pore opening channels that were poorly coupled prior to facilitation exhibited the largest facilitation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism*
  • Calcium Channels / physiology
  • Electrophysiology
  • Heart / physiology
  • Membrane Potentials
  • Myocardium / metabolism*
  • Oocytes
  • Rabbits
  • Xenopus

Substances

  • Calcium Channels
  • Calcium