Epstein-Barr virus: LMP1 masquerades as an active receptor

Curr Biol. 1998 Mar 12;8(6):R196-8. doi: 10.1016/s0960-9822(98)70123-x.

Abstract

The Epstein-Barr virus protein LMP1 is essential for transformation of resting B cells by the virus, but how it works is unclear. Recent results suggest that LMP1 acts as a constitutively active receptor that shares certain characteristics with members of the tumour necrosis factor receptor superfamily.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Viral / physiology
  • Herpesvirus 4, Human / physiology*
  • Humans
  • NF-kappa B / metabolism*
  • Signal Transduction
  • Viral Matrix Proteins / physiology*

Substances

  • EBV-associated membrane antigen, Epstein-Barr virus
  • NF-kappa B
  • Viral Matrix Proteins