Apomorphine self-injection is not affected by alpha-methylparatyrosine treatment: support for dopaminergic reward

Pharmacol Biochem Behav. 1976 May;4(5):611-2. doi: 10.1016/0091-3057(76)90205-7.

Abstract

Pretreatment with AMPT at doses which markedly altered the self-injection or amphetamine did not affect the self-injection of apomorphine. These data support the idea that the self-injection of apomorphine is produced via the direct activation of dopamine receptors rather than by the release of either norepinephrine or dopamine.

MeSH terms

  • Amphetamine / administration & dosage
  • Animals
  • Apomorphine / administration & dosage*
  • Conditioning, Operant / drug effects*
  • Dopamine*
  • Female
  • Methyltyrosines / pharmacology*
  • Rats
  • Receptors, Drug / drug effects*
  • Reinforcement Schedule
  • Reward*
  • Time Factors

Substances

  • Methyltyrosines
  • Receptors, Drug
  • Amphetamine
  • Apomorphine
  • Dopamine