Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1

Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7. doi: 10.1006/bbrc.1998.8291.


Protein tyrosine phosphatases (PTPs) play a fundamental role in regulating diverse cellular processes. PRL-1 is a unique nuclear PTP that is induced in mitogen-stimulated cells and regenerating liver. Database searches using the PRL-1 sequence led to the identification of mouse PRL-2 and PRL-3 which exhibit 87% and 76% identity to mouse PRL-1 in their amino acid sequences. All three mouse PRL proteins contain a C-terminal consensus sequence for prenylation. All PRL proteins bear significant sequence homology to Cdc14p and the recently identified tumor suppressor PTEN/MMAC1, in regions other than the conserved PTP signature motif. The nucleotide sequences of the coding regions of mouse PRL-2 and PRL-3 are, respectively, 71% and 62%, identical to mouse PRL-1, while the 5' un-translated regions of mouse PRL-1, PRL-2, and PRL-3 are much more divergent. Northern blot analysis revealed that PRL-2 is preferentially expressed in skeletal muscle, while PRL-3 is preferentially expressed in both skeletal muscle and heart, although both PRL-2 and PRL-3 are expressed at lower levels in other tissues.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Cycle Proteins
  • Consensus Sequence
  • DNA, Complementary / genetics
  • Gene Expression
  • Humans
  • Immediate-Early Proteins / chemistry
  • Immediate-Early Proteins / genetics*
  • Membrane Proteins
  • Mice
  • Molecular Sequence Data
  • Neoplasm Proteins
  • Protein Prenylation
  • Protein Tyrosine Phosphatases / chemistry
  • Protein Tyrosine Phosphatases / genetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid


  • Cell Cycle Proteins
  • DNA, Complementary
  • Immediate-Early Proteins
  • Membrane Proteins
  • Neoplasm Proteins
  • Ptp4a3 protein, mouse
  • RNA, Messenger
  • PTP4A1 protein, human
  • PTP4A3 protein, human
  • Protein Tyrosine Phosphatases
  • Ptp4a1 protein, mouse
  • Ptp4a2 protein, mouse

Associated data

  • GENBANK/AF035644
  • GENBANK/AF035645