Do transmembrane protein superfolds exist?

FEBS Lett. 1998 Feb 27;423(3):281-5. doi: 10.1016/s0014-5793(98)00095-7.


A reliable and widely used transmembrane protein structure prediction algorithm was applied to five representative genomic sequence data sets in order to re-examine the hypothesis that in contrast to globular proteins there are no favored transmembrane protein fold families. When the number of predicted membrane spanning segments and the topology of these segments is taken into account then definite biases are observed which suggest that certain transmembrane topologies are significantly more common than others.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Databases as Topic
  • Evolution, Molecular
  • Genome
  • Membrane Proteins / chemistry*
  • Open Reading Frames / genetics
  • Protein Folding*


  • Membrane Proteins