The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis

Crit Rev Oncog. 1997;8(1):71-92. doi: 10.1615/critrevoncog.v8.i1.40.


The biological actions of the insulin-like growth factors IGF-I and IGF-II are mediated by their activation of the IGF-IR, a transmembrane tyrosine kinase linked to the ras-raf-MAPK cascade. Functional IGF-IRs are required for the cell to progress through the cell cycle. Most importantly, cells lacking this receptor cannot be transformed by any of a number of dominant oncogenes, a finding that proves that the presence of the IGF-IR is important for the development of a malignant phenotype. Consistent with this role, the IGF-IR displays a potent antiapoptotic effect, both in vitro and in vivo. Because of its key role in the transformation process, the IGF-IR is actively studied as a potential therapeutic target in different types of neoplastic growth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Cell Cycle
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Developmental
  • Genes, Tumor Suppressor
  • Humans
  • Mice
  • Mice, Knockout
  • Oncogenes
  • Protein Conformation
  • Receptors, Somatomedin / chemistry
  • Receptors, Somatomedin / genetics
  • Receptors, Somatomedin / metabolism*
  • Signal Transduction*


  • Receptors, Somatomedin