Ibotenic acid lesions of the parabrachial nucleus and conditioned taste aversion: further evidence for an associative deficit in rats

Behav Neurosci. 1998 Feb;112(1):160-71.

Abstract

Rats with extensive ibotenic acid lesions centered in the gustatory zone of the pontine parabrachial nucleus (PBN) failed to acquire a conditioned taste aversion (CTA) induced by lithium chloride (LiCl) toxicosis (Experiments 1 and 4). This deficit cannot be explained as an inability to either perceive or process gustatory information because lesioned rats that failed to acquire a CTA readily acquired a conditioned flavor preference (Experiment 2). Similarly, the CTA deficit cannot be attributed to an inability to experience or process visceral input because PBN-lesioned rats that failed to acquire a CTA successfully learned an aversion to a trigeminal stimulus, capsaicin, when paired with LiCl-induced illness (Experiment 3). This pattern of results supports the view that cell bodies within the PBN are essential for the associative processes that govern CTA learning.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Association Learning / physiology*
  • Avoidance Learning / physiology*
  • Brain Mapping
  • Capsaicin
  • Conditioning, Classical / physiology*
  • Ibotenic Acid
  • Lithium Chloride / toxicity
  • Male
  • Mental Recall / physiology*
  • Pons / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Solitary Nucleus / physiology*
  • Taste / physiology*
  • Trigeminal Nerve / physiology

Substances

  • Ibotenic Acid
  • Lithium Chloride
  • Capsaicin