Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens

Brain Res. 1998 Mar 23;787(2):304-10. doi: 10.1016/s0006-8993(97)01373-5.

Abstract

The prefrontal cortex and nucleus accumbens are primary recipients of medial thalamic inputs, prominently including projections from the thalamic paraventricular nucleus. It is not known if paraventricular neurons collateralize to innervate both the prefrontal cortex and nucleus accumbens. We used dual retrograde tract tracing methods to examine this question. A small population of paraventricular neurons was found to innervate the prefrontal cortex and medial nucleus accumbens. These data suggest that the thalamic paraventricular nucleus may coordinately influence activity in the prefrontal cortex and ventral striatum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amidines
  • Animals
  • Fluorescent Dyes
  • Immunohistochemistry
  • Male
  • Neurons, Afferent / physiology*
  • Nucleus Accumbens / cytology
  • Nucleus Accumbens / physiology*
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Stilbamidines*
  • Thalamic Nuclei / cytology
  • Thalamic Nuclei / physiology*

Substances

  • 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt
  • Amidines
  • Fluorescent Dyes
  • Stilbamidines
  • diamidino compound 253-50