Abstract
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Archaeal Proteins
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Binding Sites
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DNA / chemistry
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DNA / metabolism*
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DNA Topoisomerases, Type II* / chemistry*
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DNA Topoisomerases, Type II* / metabolism
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Models, Molecular
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Nucleic Acid Conformation
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Protein Conformation
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Structure-Activity Relationship
Substances
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Archaeal Proteins
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DNA
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DNA topoisomerase VI
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DNA Topoisomerases, Type II