Type II DNA topoisomerases

Curr Opin Struct Biol. 1998 Feb;8(1):26-32. doi: 10.1016/s0959-440x(98)80006-7.

Abstract

Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Archaeal Proteins
  • Binding Sites
  • DNA / chemistry
  • DNA / metabolism*
  • DNA Topoisomerases, Type II* / chemistry*
  • DNA Topoisomerases, Type II* / metabolism
  • Models, Molecular
  • Nucleic Acid Conformation
  • Protein Conformation
  • Structure-Activity Relationship

Substances

  • Archaeal Proteins
  • DNA
  • DNA topoisomerase VI
  • DNA Topoisomerases, Type II