The cyclin family of budding yeast: abundant use of a good idea

Trends Genet. 1998 Feb;14(2):66-72. doi: 10.1016/s0168-9525(97)01322-x.


Cyclins are highly conserved proteins that activate cyclin-dependent kinases (CDKs) to regulate the cell cycle, transcription and other cellular processes. The completion of the genome sequence of the budding yeast Saccharomyces cerevisiae allows an appraisal of the functions of the entire complement of cyclins in a eukaryotic organism. The cyclin family of budding yeast is reviewed from a functional perspective with an emphasis on what genetic and biochemical experiments have revealed about cyclin-CDK substrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CDC28 Protein Kinase, S cerevisiae / genetics
  • CDC28 Protein Kinase, S cerevisiae / metabolism
  • Cyclin-Dependent Kinases / genetics
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / genetics
  • Cyclins / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins*
  • Transcription, Genetic


  • Cyclins
  • Saccharomyces cerevisiae Proteins
  • CDC28 Protein Kinase, S cerevisiae
  • Cyclin-Dependent Kinases
  • PHO85 protein, S cerevisiae