Dendritic Cells and the Control of Immunity

Nature. 1998 Mar 19;392(6673):245-52. doi: 10.1038/32588.

Abstract

B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • B-Lymphocytes / immunology
  • Cell Differentiation
  • Cell Movement
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Forecasting
  • Humans
  • Immunity / physiology*
  • Self Tolerance / immunology
  • T-Lymphocytes / immunology