Effects of nasal administration of calcitonin in oophorectomized women: 2-year controlled double-blind study

Maturitas. 1997 Dec 15;28(2):147-51. doi: 10.1016/s0378-5122(97)00071-6.


Objective: The aim of this study was to assess the effects of nasal salmon calcitonin (SCT) administration on bone turnover in ovariectomized women.

Methods: Patients who had undergone bilateral ovariectomy 7 days previously, received either calcium supplementation (1000 mg/day, together with nasal SCT (100 IU/day) (n = 19) or the same calcium supplementation together with a placebo intranasal spray daily (n = 19), for 2 years.

Results: In the calcium-only-treated subjects, lumbar bone mineral density (BMD) was found to have decreased significantly (P < 0.001), 6 months after surgery and remained at this level until the end of the study. In the SCT-treated group, BMD remained stable during the 1st year and then decreased gradually, reaching a statistically significant level in the 2nd year. Mean serum osteocalcin concentration was unchanged during the 1st year of SCT treatment but was significantly elevated during the 2nd year (P < 0.01). The observed rise in serum osteocalcin concentration and urinary hydroxyproline excretion during the 2nd year of treatment with SCT was accompanied by a significant rise in serum calcitonin levels (P < 0.001 after 18 months and P < 0.01 after 24 months).

Conclusion: This study shows that continuous treatment with intranasal SCT is able to prevent the bone loss that follows ovariectomy.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intranasal
  • Adult
  • Analgesics / administration & dosage
  • Analgesics / pharmacology*
  • Bone Density / drug effects*
  • Bone Density / physiology
  • Calcitonin / administration & dosage
  • Calcitonin / pharmacology*
  • Calcium / urine
  • Cohort Studies
  • Creatinine / urine
  • Double-Blind Method
  • Female
  • Humans
  • Hydroxyproline / urine
  • Middle Aged
  • Osteocalcin / blood
  • Ovariectomy
  • Postmenopause / drug effects*
  • Postmenopause / physiology


  • Analgesics
  • Osteocalcin
  • salmon calcitonin
  • Calcitonin
  • Creatinine
  • Hydroxyproline
  • Calcium