[Prospective randomized pilot study of ambulatory prevention of thromboembolism. 2 times 500 mg aspirin (ASS) vs. clivarin 1750 (NMH)]

Unfallchirurg. 1998 Jan;101(1):42-9. doi: 10.1007/s001130050231.
[Article in German]

Abstract

From March 1994 to March 1996, 287 patients, presenting with lower extremity injuries, who required immobilizing bandages or casts, where included in a prospective, randomized study. These patients received either low-molecular heparin or acetylsalicylic acid for thrombosis prophylaxis. In all patients a clinical examination and a colour-coded duplex sonography were performed after removal of the cast for detection of lower extremity venous thrombosis. A plebography was performed when thrombosis was suspected. A subcutaneous injection of divarin 1750 was given once daily in 143 patients. Thrombosis prophylaxis with Aspirin 2 x 500 mg administered orally was performed in 144 patients. Deep vein thrombosis occurred in 9 patients (6.3%) with clivarin prophylaxis and in 7 patients (4.8%) treated with Aspirin. In both groups, no clinically significant side effects of the medications were observed.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Ambulatory Care
  • Anticoagulants / administration & dosage*
  • Aspirin / administration & dosage*
  • Casts, Surgical*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Heparin, Low-Molecular-Weight / administration & dosage*
  • Humans
  • Leg Injuries / complications
  • Leg Injuries / therapy*
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Thromboembolism / prevention & control*

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • reviparin
  • Aspirin