The mannose receptor is a pattern recognition receptor involved in host defense

Curr Opin Immunol. 1998 Feb;10(1):50-5. doi: 10.1016/s0952-7915(98)80031-9.


The mannose receptor recognizes the patterns of carbohydrates that decorate the surfaces and cell walls of infectious agents. This macrophage and dendritic cell pattern-recognition receptor mediates endocytosis and phagocytosis. The mannose receptor is the prototype of a new family of multilectin receptor proteins (membrane-spanning receptors containing eight-ten lectin-like domains, which appear to play a key role in host defense) and provides a link between innate and adaptive immunity. Recent advances include the identification of three new members of the mannose receptor family, additional work on defining the molecular requirements for sugar binding, a role for the mannose receptor in antigen presentation of lipoglycan antigens and evidence that the mannose receptor is associated with a signal transduction pathway leading to cytokine production.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Humans
  • Immunity / immunology
  • Immunity, Innate / immunology
  • Mannose / immunology*
  • Receptors, Cell Surface / immunology*


  • Receptors, Cell Surface
  • Mannose