Sarcoidosis: family contact study

Respiration. 1998;65(1):34-9. doi: 10.1159/000029225.


Aim: To assess the familial aggregation in sarcoidosis in our environment.

Methods: The medical centers of Catalonia (Spain) were approached to identify, retrospectively, patients diagnosed as sarcoidosis from 1986 to 1988. 245 sarcoidosis cases were recorded (annual incidence: 1.36/100,000 inhabitants). Finally, in 1990 a telephone questionnaire was administered to 188 sarcoidosis cases.

Results: These cases reported 3,757 familial contacts, 5 of whom had confirmed sarcoidosis. The clinical presentation of familial sarcoidosis was similar to nonfamilial sarcoidosis, only Löfgren syndrome stood out. The prevalence of sarcoidosis among familial contacts was 1.33/1,000.

Conclusions: The familial association is low and corresponds with the low annual incidence in our community.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Cross-Sectional Studies
  • Female
  • Health Surveys
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Prevalence
  • Retrospective Studies
  • Sarcoidosis / epidemiology*
  • Sarcoidosis / genetics*
  • Sex Distribution
  • Spain / epidemiology
  • Survival Rate