Characterization of the human gene coding for the swelling-dependent chloride channel ICln at position 11q13.5-14.1 (CLNS1A) and further characterization of the chromosome 6 (CLNS1B) localization

Gene. 1998 Mar 16;209(1-2):59-63. doi: 10.1016/s0378-1119(98)00002-x.

Abstract

Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chloride Channels / biosynthesis
  • Chloride Channels / chemistry
  • Chloride Channels / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 6*
  • DNA Primers
  • Exons
  • Genomic Library
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Ion Channels*
  • Molecular Sequence Data
  • Open Reading Frames
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Substances

  • CLNS1A protein, human
  • Chloride Channels
  • DNA Primers
  • Ion Channels