Renal effects of alpha-ketoglutarate early after coronary operations

Ann Thorac Surg. 1998 Mar;65(3):684-90. doi: 10.1016/s0003-4975(97)01337-4.

Abstract

Background: Alpha-ketoglutarate (alpha-KG) is a Krebs cycle intermediate and the carbon skeleton of glutamate. Alpha-ketoglutarate has provoked interest in heart surgery because of its proposed critical role in myocardial metabolism. This study investigates the role of alpha-KG in renal function after cardiac surgical procedures.

Methods: Twenty-two patients with normal preoperative renal function were included in a prospective, randomized, and controlled study. Eleven patients received intravenous infusion of 30 g alpha-KG/hour after the operation. Measurements were performed before operation, immediately after operation, and after 30 minutes of alpha-KG infusion.

Results: Renal blood flow was higher during alpha-KG infusion, 297% +/- 97% (of preoperative value), than in controls, 125% +/- 20% (p < 0.05). Filtration fraction was lower (12.3% +/- 0.05% versus 17.2% +/- 1.1%, p < 0.01), which prevented a significant difference in glomerular filtration rate. The renal arteriovenous differences of lactate, glutamate, glutamine, and glycine changed toward a net release during alpha-KG infusion.

Conclusions: Infusion of alpha-KG enhances renal blood flow early after coronary surgical procedures in patients with normal renal function. The mechanism is unclear, but could be associated with primarily metabolic effects, and may potentially convey a beneficial effect for renal function.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiac Surgical Procedures*
  • Glomerular Filtration Rate
  • Glutamates / blood
  • Glycine / blood
  • Humans
  • Ketoglutaric Acids / administration & dosage
  • Ketoglutaric Acids / pharmacology*
  • Kidney / drug effects*
  • Lactates / blood
  • Male
  • Middle Aged
  • Prospective Studies
  • Renal Circulation / drug effects

Substances

  • Glutamates
  • Ketoglutaric Acids
  • Lactates
  • Glycine