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, 8 (3), 319-29

Crystal Structures of Two I-Ad-peptide Complexes Reveal That High Affinity Can Be Achieved Without Large Anchor Residues

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Crystal Structures of Two I-Ad-peptide Complexes Reveal That High Affinity Can Be Achieved Without Large Anchor Residues

C A Scott et al. Immunity.

Erratum in

  • Immunity 1998 Apr;8(4):531

Abstract

We have determined the structures of I-Ad covalently linked to an ovalbumin peptide (OVA323-339) and to an influenza virus hemagglutinin peptide (HA126-138). The floor of the peptide-binding groove contains an unusual beta bulge, not seen in I-E and DR structures, that affects numerous interactions between the alpha and beta chains and bound peptide. Unlike other MHC-peptide complexes, the peptides do not insert any large anchor residues into the binding pockets of the shallow I-Ad binding groove. The previously identified six-residue "core" binding motif of I-Ad occupies only the P4 to P9 pockets, implying that specificity of T cell receptor recognition of I-Ad-peptide complexes can be accomplished by peptides that only partially fill the MHC groove.

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