Mechanism of activation and function of protein kinase B

Curr Opin Genet Dev. 1998 Feb;8(1):55-62. doi: 10.1016/s0959-437x(98)80062-2.


The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.

Publication types

  • Review

MeSH terms

  • 3-Phosphoinositide-Dependent Protein Kinases
  • Amino Acid Sequence
  • Animals
  • Enzyme Activation
  • Humans
  • Molecular Sequence Data
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphatidylinositols / metabolism
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction
  • Threonine / metabolism


  • Phosphatidylinositols
  • Proto-Oncogene Proteins
  • Threonine
  • Phosphatidylinositol 3-Kinases
  • 3-Phosphoinositide-Dependent Protein Kinases
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt