Myb proteins in life, death and differentiation

Curr Opin Genet Dev. 1998 Feb;8(1):76-81. doi: 10.1016/s0959-437x(98)80065-8.

Abstract

Myb transcription factors are crucial to the control of proliferation and differentiation in a number of cell types but their mechanism of action is unclear. Regulation of Myb proteins by phosphorylation and intermolecular cooperation has recently been demonstrated, together with a new role for the proteins, in the control of apoptosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins*
  • Cell Death
  • Cell Differentiation
  • Cell Survival
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Humans
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-myb
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • MYBL1 protein, human
  • MYBL2 protein, human
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myb
  • Trans-Activators
  • Transcription Factors