Beta-catenin: a key mediator of Wnt signaling

Curr Opin Genet Dev. 1998 Feb;8(1):95-102. doi: 10.1016/s0959-437x(98)80068-3.


Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism
  • Cytoskeletal Proteins / physiology*
  • DNA-Binding Proteins / metabolism
  • Drosophila Proteins*
  • Humans
  • Lymphoid Enhancer-Binding Factor 1
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction*
  • Trans-Activators*
  • Transcription Factors / metabolism
  • Wnt1 Protein
  • beta Catenin


  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • Wnt1 Protein
  • beta Catenin
  • wg protein, Drosophila