Increasing prevalence of Kingella kingae in osteoarticular infections in young children

J Pediatr Orthop. Mar-Apr 1998;18(2):262-7.

Abstract

Sixty children younger than 3 years with culture-positive hematogenous septic arthritis and acute/subacute osteomyelitis treated between 1990 and 1995 were reviewed to identify the infecting organism. Gram-positive bacteria were identified in 47 (78.3%) patients, and gram-negative organisms were identified in 13 (21.7%) patients. Haemophilus influenzae was cultured in none of the cases of septic arthritis and in only one (1.6%) case of acute osteomyelitis. Kingella kingae was cultured in 10 (16.7%) cases, with all of these patients between the ages of 10.5 and 23.5 months. Routine immunization of infants against H. influenzae has caused a change in the historically reported bacteria of bone and joint infections in children younger than 3 years. Haemophilus influenzae has lost its predominance as the most commonly identified gram-negative pathogen, and in this study, has been replaced by K. kingae.

MeSH terms

  • Age Factors
  • Anti-Bacterial Agents / therapeutic use
  • Arthritis, Infectious / diagnostic imaging
  • Arthritis, Infectious / drug therapy
  • Arthritis, Infectious / epidemiology*
  • Arthritis, Infectious / microbiology*
  • Child, Preschool
  • Escherichia coli Infections / epidemiology
  • Female
  • Gram-Negative Bacteria / isolation & purification
  • Haemophilus Infections / epidemiology
  • Haemophilus influenzae / isolation & purification
  • Humans
  • Infant
  • Kingella kingae / isolation & purification*
  • Male
  • Neisseriaceae Infections / diagnosis
  • Neisseriaceae Infections / epidemiology*
  • Prevalence
  • Radiography
  • Retrospective Studies
  • United States / epidemiology

Substances

  • Anti-Bacterial Agents