Identification and characterization of a myomodulin-like peptide in the leech

Peptides. 1998;19(3):487-93. doi: 10.1016/s0196-9781(97)00419-1.


A novel myomodulin-like peptide, GMGALRLamide, has been purified and sequenced from extracts of 1000 medicinal leech nerve cords. Synthetic leech myomodulin-like peptide blocked the specific staining pattern of leech ganglia by the antiserum against Aplysia myomodulin A PMGMLRLamide. Moreover, the synthetic leech myomodulin-like peptide GMGALRLamide showed identical neuronal modulation effect on the giant leech Retzius cell compare to that by the synthetic Aplysia myomodulin A PMGMLRLamide.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatography, High Pressure Liquid
  • Immunoassay
  • Leeches / chemistry*
  • Molecular Sequence Data
  • Neuropeptides / chemistry
  • Neuropeptides / isolation & purification*


  • Neuropeptides
  • myomodulin