Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

Pharmacol Ther. Oct-Dec 1997;76(1-3):219-42. doi: 10.1016/s0163-7258(97)00094-6.


Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacokinetics
  • Drug Resistance, Microbial*
  • Drug Resistance, Multiple*
  • Humans
  • Phenotype
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / genetics


  • ATP-Binding Cassette Transporters
  • Antifungal Agents
  • Antineoplastic Agents