Metipranolol-associated nongranulomatous anterior uveitis

Am J Ophthalmol. 1997 Jun;123(6):843-4. doi: 10.1016/s0002-9394(14)71139-0.


Purpose: To describe the findings in a patient with a nongranulomatous anterior uveitis, presumed to be induced by metipranolol.

Method: A 69-year-old woman developed bilateral, nongranulomatous, anterior uveitis while undergoing treatment with metipranolol 0.3% for primary open-angle glaucoma. Four months after resolution of the initial episode, the patient was challenged with metipranolol 0.3% in the right eye.

Result: On reinstituting metipranolol 0.3%, the patient once again developed a unilateral, nongranulomatous, anterior uveitis in the challenged eye.

Conclusion: Metipranolol 0.3% eyedrops, used to treat primary open-angle glaucoma, appear to cause a nongranulomatous anterior uveitis.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects*
  • Adrenergic beta-Antagonists / therapeutic use
  • Aged
  • Female
  • Glaucoma, Open-Angle / drug therapy
  • Granuloma / chemically induced
  • Humans
  • Intraocular Pressure
  • Metipranolol / adverse effects*
  • Metipranolol / therapeutic use
  • Ophthalmic Solutions
  • Recurrence
  • Uveitis, Anterior / chemically induced*
  • Visual Acuity


  • Adrenergic beta-Antagonists
  • Ophthalmic Solutions
  • Metipranolol