Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

Hum Mol Genet. 1998 May;7(5):933-5. doi: 10.1093/hmg/7.5.933.


The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE . Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • Butyrylcholinesterase / genetics*
  • Chromosomes, Human, Pair 3 / genetics*
  • Female
  • Gene Frequency
  • Genetic Markers
  • Humans
  • Male
  • Middle Aged


  • Apolipoprotein E4
  • Apolipoproteins E
  • Genetic Markers
  • Butyrylcholinesterase