Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus

Baillieres Clin Obstet Gynaecol. 1997 Jun;11(2):335-47. doi: 10.1016/s0950-3552(97)80040-5.


Up to 40% of women with polycystic ovary syndrome (PCOS) demonstrate some degree of glucose intolerance, either impaired glucose tolerance (IGT) or non-insulin dependent diabetes mellitus (NIDDM). Defects in insulin action have long-been recognized as characteristic in these women. Recently, evidence has been obtained which documents that insulin secretory dysfunction also contributes significantly to the observed glucose intolerance. This chapter will focus on the recent evidence supporting the specific roles of disordered insulin secretion and action, in the development of glucose intolerance in PCOS. In addition, the use of pharmacological agents that modify insulin action as therapeutic options for women with PCOS, will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Glucose Intolerance
  • Humans
  • Hyperandrogenism / complications*
  • Insulin Resistance
  • Polycystic Ovary Syndrome / complications*