Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 392 (6674), 398-401

A Mutation in the Human Leptin Receptor Gene Causes Obesity and Pituitary Dysfunction

Affiliations

A Mutation in the Human Leptin Receptor Gene Causes Obesity and Pituitary Dysfunction

K Clément et al. Nature.

Abstract

The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure. Leptin acts through the leptin receptor, a single-transmembrane-domain receptor of the cytokine-receptor family. In rodents, homozygous mutations in genes encoding leptin or the leptin receptor cause early-onset morbid obesity, hyperphagia and reduced energy expenditure. These rodents also show hypercortisolaemia, alterations in glucose homeostasis, dyslipidaemia, and infertility due to hypogonadotropic hypogonadisms. In humans, leptin deficiency due to a mutation in the leptin gene is associated with early-onset obesity. Here we describe a homozygous mutation in the human leptin receptor gene that results in a truncated leptin receptor lacking both the transmembrane and the intracellular domains. In addition to their early-onset morbid obesity, patients homozygous for this mutation have no pubertal development and their secretion of growth hormone and thyrotropin is reduced. These results indicate that leptin is an important physiological regulator of several endocrine functions in humans.

Comment in

Similar articles

See all similar articles

Cited by 360 PubMed Central articles

See all "Cited by" articles

Publication types

Feedback