Cloning and characterization of MUPP1, a novel PDZ domain protein

FEBS Lett. 1998 Mar 6;424(1-2):63-8. doi: 10.1016/s0014-5793(98)00141-0.


Using the yeast two-hybrid system we isolated a cDNA clone encoding a novel protein interacting with the C-terminal domain of the 5-HT2C receptor. The protein, named MUPP1 (multi-PDZ-domain protein), contains thirteen PDZ domains and no obvious catalytic domain; it is related to hINADL and a putative C. elegans polypeptide referred to as C52A11.4 containing six or ten PDZ domains, respectively. Domains highly similar to those of MUPP1 are arrayed in the same order in all three proteins. The MUPP1 gene is localized on human chromosome 9p24-p22. Transcripts encoding MUPP1 are abundant in the brain as well as in several peripheral organs.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • Carrier Proteins / genetics*
  • Carrier Proteins / isolation & purification*
  • Chromosome Mapping
  • DNA, Complementary / analysis
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Sequence Data
  • Protein Conformation
  • RNA, Messenger / metabolism
  • Rats
  • Receptor, Serotonin, 5-HT2C
  • Receptors, Serotonin / chemistry
  • Receptors, Serotonin / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Carrier Proteins
  • DNA, Complementary
  • Intracellular Signaling Peptides and Proteins
  • MPDZ protein, human
  • Membrane Proteins
  • Mpdz protein, rat
  • RNA, Messenger
  • Receptor, Serotonin, 5-HT2C
  • Receptors, Serotonin

Associated data

  • GENBANK/AJ001319
  • GENBANK/AJ001320