Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas

Int J Oncol. 1998 May;12(5):1085-90. doi: 10.3892/ijo.12.5.1085.

Abstract

Fibroblast growth factor (FGF) signaling has been recognized in human gliomas. We tested the effect of FGF-2 and FGF-9 on the proliferation and the expression of matrix metalloproteinases (MMPs) and their inhibitor (TIMP-1) in vitro. Both FGFs showed mitogenic activity on U251MG and NMC-G1 cells. MMP-1 expression and collagenolytic activity of NMC-G1 but not of U251MG, and TIMP-1 expression of both cells were stimulated by FGFs. MMP-2 expression, gelatinolytic activity, and chemoinvasion on the matrigel were not altered. FGFs may regulate proliferation and microenvironmental factors independently in each glioma type.

MeSH terms

  • Brain Neoplasms / enzymology*
  • Brain Neoplasms / pathology*
  • Cell Division / drug effects
  • Collagenases / biosynthesis
  • Fibroblast Growth Factor 2 / pharmacology*
  • Fibroblast Growth Factor 9
  • Fibroblast Growth Factors*
  • Gelatinases / biosynthesis
  • Gene Expression Regulation, Enzymologic / drug effects
  • Glioma / enzymology*
  • Glioma / pathology*
  • Growth Substances / pharmacology*
  • Humans
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 2
  • Metalloendopeptidases / biosynthesis*
  • Neoplasm Invasiveness
  • Tissue Inhibitor of Metalloproteinase-1 / biosynthesis
  • Tumor Cells, Cultured

Substances

  • FGF9 protein, human
  • Fibroblast Growth Factor 9
  • Growth Substances
  • Tissue Inhibitor of Metalloproteinase-1
  • Fibroblast Growth Factor 2
  • Fibroblast Growth Factors
  • Collagenases
  • Gelatinases
  • Metalloendopeptidases
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 1