An atlas of serpin conformations

Trends Biochem Sci. 1998 Feb;23(2):63-7. doi: 10.1016/s0968-0004(97)01172-9.


The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed-->relaxed (S-->R) transition. This article is a guide to the known serpin conformations and their biological significance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Serpins / chemistry*
  • Serpins / genetics


  • Serpins