Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values

J Cereb Blood Flow Metab. 1998 Apr;18(4):425-32. doi: 10.1097/00004647-199804000-00011.


The authors determined cerebral blood flow (CBF) with magnetic resonance imaging (MRI) of contrast agent bolus passage and compared the results with those obtained by O-15 labeled water (H215O) and positron emission tomography (PET). Six pigs were examined by MRI and PET under normo- and hypercapnic conditions. After dose normalization and introduction of an empirical constant phi Gd, absolute regional CBF was calculated from MRI. The spatial resolution and the signal-to-noise ratio of CBF measurements by MRI were better than by the H215O-PET protocol. Magnetic resonance imaging cerebral blood volume (CBV) estimates obtained using this normalization constant correlated well with values obtained by O-15 labeled carbonmonooxide (C15O) PET. However, PET CBV values were approximately 2.5 times larger than absolute MRI CBV values, supporting the hypothesized sensitivity of MRI to small vessels.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Volume
  • Carbon Monoxide / pharmacokinetics
  • Cerebrovascular Circulation*
  • Contrast Media / administration & dosage
  • Contrast Media / pharmacokinetics
  • Female
  • Hypercapnia / diagnostic imaging
  • Hypercapnia / physiopathology*
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Oxygen Radioisotopes / pharmacokinetics
  • Swine
  • Tomography, Emission-Computed*


  • Contrast Media
  • Oxygen Radioisotopes
  • Carbon Monoxide