Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet

Int J Obes Relat Metab Disord. 1998 Mar;22(3):195-9. doi: 10.1038/sj.ijo.0800566.


Objective: To examine the effect of diet with exercise on serum leptin and whether leptin is associated with the metabolic syndrome X in a high risk population such as overweight postmenopausal women.

Study design and subjects: 121 healthy overweight, postmenopausal women (aged 49-58y, body mass index (BMI) 25-42 kg/m2) were randomized to: A low-energy-diet, 4.2 MJ/d (n = 51), low-energy-diet + standardized physical exercise (n=49) or no intervention (control: n=21) for 12 weeks, followed by 6 months follow-up without intervention.

Measurements: S-leptin was measured by Radio Immuno Assay (RIA), body composition and fat distribution by dual energy X-ray absorptiometry (DEXA) and anthropometry. Factors associated with the metabolic syndrome X and sex hormones were measured.

Results: S-leptin was two-fold higher than in normal-weight postmenopausal women and S-leptin was normalized after weight loss induced by the 12-week low-energy-diet, without any additive effect of the exercise. Of the factors associated with the metabolic syndrome X, serum-leptin correlated significantly only with sex-hormone-binding-globulin and plasminogen-activator-inhibitor-1, whereas factors associated with obesity per se correlated significantly with leptin. Changes in S-leptin correlated with changes in fat tissue mass during the follow-up, but not during the intervention. S-leptin at baseline did not correlate with either short term or long term weight loss.

Conclusion: There is no effect of exercise added to diet on S-leptin in overweight postmenopausal women. Leptin does not seem to be associated with the metabolic syndrome X, but rather with fatness. S-leptin is probably associated with both dynamic and static effects of adipose tissue. S-leptin did not predict weight loss.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Composition
  • Cohort Studies
  • Diet, Reducing*
  • Exercise / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Leptin
  • Linear Models
  • Middle Aged
  • Obesity / blood*
  • Obesity / therapy
  • Plasminogen Activator Inhibitor 1 / analysis
  • Postmenopause / blood*
  • Proteins / analysis*
  • Radioimmunoassay
  • Sex Hormone-Binding Globulin / analysis


  • Leptin
  • Plasminogen Activator Inhibitor 1
  • Proteins
  • Sex Hormone-Binding Globulin