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Clinical Trial
. 1998 Mar;22(3):227-9.
doi: 10.1038/sj.ijo.0800573.

Increased Estrogen 2-hydroxylation in Obese Women Using Oral indole-3-carbinol

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Clinical Trial

Increased Estrogen 2-hydroxylation in Obese Women Using Oral indole-3-carbinol

J J Michnovicz. Int J Obes Relat Metab Disord. .

Abstract

Objective: To investigate whether the dietary phytochemical, indole-3-carbinol (13C), influences the level of estradiol 2-hydroxylation in obese women.

Design: A clinical intervention study involving the ingestion of purified 13C, 400 mg, for two months.

Subjects: Five healthy, overweight, premenopausal women (age: 35-47 y, body mass index (BMI): 27-53 kg/m2).

Measurements: Two estrogen metabolites, 2-hydroxyestrone (2OHE1) and estriol (E3), were measured by radioimmunoassay in untimed overnight urine samples, before and after ingestion of 13C.

Results: The ratio of urinary estrogens, 2OHE1/E3, was significantly increased in obese women following 13C, reflecting induction of 2-hydroxylation in these women.

Conclusions: Obese premenopausal women experience increased estrogen 2-hydroxylation in response to the dietary agent, 13C, similar to non-obese women. This response to 13C may result in a hormonal milieu that helps reduce estrogen-dependent cancer risk.

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