Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: a SPECT study using [123I] epidepride and [123I] beta-CIT

Mov Disord. 1998 Mar;13(2):319-23. doi: 10.1002/mds.870130219.


There is increasing evidence that a dysfunction of the dopaminergic system may be involved in the pathogenesis of idiopathic dystonia. To visualize possible alterations of the pre- and postsynaptic side of striatal dopaminergic synapses, SPECT studies using the radiotracers [123I] epidepride and [123I] beta-CIT were performed in 10 patients with idiopathic cervical dystonia. Eleven age- and sex-matched subjects served as controls. [123I] Epidepride is a new highly affine marker of D2 receptors, and [123I] beta-CIT binds to dopamine transporters on dopaminergic nerve endings. [123I] Epidepride binding was significantly reduced in both striata of dystonia patients compared with controls (p < 0.05). In contrast, striatal [123I beta-CIT uptake did not differ from controls. We conclude that dopaminergic dysfunction in idiopathic focal dystonia mainly involves postsynaptic mechanisms and suggest a disturbance of the indirect pathway of the motor circuit resulting in a disinhibited thalamocortical stimulation.

MeSH terms

  • Adult
  • Aged
  • Benzamides*
  • Brain Mapping
  • Carrier Proteins / physiology*
  • Cocaine / analogs & derivatives*
  • Contrast Media*
  • Corpus Striatum / diagnostic imaging*
  • Corpus Striatum / physiopathology
  • Dopamine Plasma Membrane Transport Proteins
  • Dystonia Musculorum Deformans / diagnostic imaging*
  • Dystonia Musculorum Deformans / physiopathology
  • Female
  • Humans
  • Iodine Radioisotopes
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Middle Aged
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiopathology
  • Nerve Tissue Proteins*
  • Pyrrolidines*
  • Receptors, Dopamine / physiology*
  • Tomography, Emission-Computed, Single-Photon*
  • Torticollis / diagnostic imaging*
  • Torticollis / physiopathology


  • Benzamides
  • Carrier Proteins
  • Contrast Media
  • Dopamine Plasma Membrane Transport Proteins
  • Iodine Radioisotopes
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Pyrrolidines
  • Receptors, Dopamine
  • epidepride
  • 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
  • Cocaine