Functions of the two glutamate transporters GLAST and GLT-1 in the retina

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4663-6. doi: 10.1073/pnas.95.8.4663.


In the retina, the glutamate transporter GLAST is expressed in Müller cells, whereas the glutamate transporter GLT-1 is found only in cones and various types of bipolar cells. To investigate the functional role of this differential distribution of glutamate transporters, we have analyzed GLAST and GLT-1 mutant mice. In GLAST-deficient mice, the electroretinogram b-wave and oscillatory potentials are reduced and retinal damage after ischemia is exacerbated, whereas GLT-1-deficient mice show almost normal electroretinograms and mild increased retinal damage after ischemia. These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / analysis
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Amino Acid Sequence
  • Amino Acid Transport System X-AG
  • Animals
  • Antibodies
  • Biological Transport
  • Electroretinography
  • Ischemia / genetics
  • Ischemia / pathology
  • Ischemia / physiopathology*
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Peptide Fragments / chemistry
  • Peptide Fragments / immunology
  • Retina / cytology
  • Retina / physiology*
  • Retinal Vessels*


  • ATP-Binding Cassette Transporters
  • Amino Acid Transport System X-AG
  • Antibodies
  • Peptide Fragments