Effect of hypercapnia and hypocapnia on myocardial blood flow and performance in anaesthetized dogs

Cardiovasc Res. 1976 May;10(3):341-8. doi: 10.1093/cvr/10.3.341.


The effects of hypercapnia and hypocapnia on haemodynamics, coronary blood flow, and lactate metabolism were evaluated in anaesthetized closed chest dogs. Coronary flow increased with increased pCO2 and oxygen consumption and left ventricular performance were well maintained. Hypocapnia reduced coronary flow, oxygen consumption, and left ventricular functional performance.

MeSH terms

  • Anesthesia
  • Animals
  • Carbon Dioxide / blood*
  • Coronary Circulation*
  • Dogs
  • Female
  • Hemodynamics
  • Lactates / metabolism
  • Male
  • Myocardial Contraction*
  • Myocardium / metabolism*
  • Oxygen / blood
  • Oxygen Consumption
  • Pyruvates / metabolism


  • Lactates
  • Pyruvates
  • Carbon Dioxide
  • Oxygen