The diagnostic utility of c-ANCA in Wegener's granulomatosis

Cleve Clin J Med. 1998 Mar;65(3):135-40. doi: 10.3949/ccjm.65.3.135.


Anti-neutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) have been found to have a high degree of sensitivity and specificity for Wegener's granulomatosis. Nevertheless, despite the attraction of using this autoantibody as a diagnostic test, in almost all instances it should not be used in place of a biopsy to diagnose Wegener's granulomatosis.

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic / analysis*
  • Biomarkers / analysis*
  • Biopsy
  • Diagnosis, Differential
  • Granulomatosis with Polyangiitis / diagnosis*
  • Humans
  • Sensitivity and Specificity


  • Antibodies, Antineutrophil Cytoplasmic
  • Biomarkers