Hyperemesis gravidarum associated with Helicobacter pylori seropositivity

Obstet Gynecol. 1998 Apr;91(4):615-7. doi: 10.1016/s0029-7844(97)00709-6.


Objective: To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum.

Methods: From January 1995 to November 1996 we enrolled 105 patients with hyperemesis gravidarum in a prospective study. The Helicobacter serum Immunoglobulin (Ig) G concentrations in these patients were compared with those in asymptomatic gravidas matched for week of gestation.

Results: Positive serum IgG concentrations were found in 95 of the 105 hyperemesis patients (90.5%) compared with 60 of 129 controls (46.5%). A chi2 test showed statistical significance (P < .001). The mean (+/-standard deviation) index percentages of the IgG titers were 74.2+/-23.6% in the hyperemesis group and 24.3+/-4.4% in the control group (P < .01, Student t test).

Conclusion: Infection with H pylori may cause hyperemesis gravidarum.

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Fluoroimmunoassay
  • Helicobacter Infections / complications*
  • Helicobacter Infections / diagnosis
  • Helicobacter pylori*
  • Humans
  • Hyperemesis Gravidarum / complications*
  • Hyperemesis Gravidarum / microbiology
  • Immunoglobulin G / blood
  • Pregnancy
  • Prospective Studies
  • Serologic Tests


  • Immunoglobulin G