Comparison of Fucithalmic viscous eye drops and Chloramphenicol eye ointment as a single treatment in corneal abrasion

Acta Ophthalmol Scand. 1998 Feb;76(1):108-11. doi: 10.1034/j.1600-0420.1998.760121.x.


Purpose: To compare the healing of the cornea and the incidence of infection after traumatic corneal epithelial defect after single treatment with double bandage combined with either Fucithalmic single unit dose eye drops or chloramphenicol eye ointment.

Methods: This is a single-centre, randomised, single-blind, parallel-group study of 144 patients with accidental corneal abrasion or corpus alieni cornea who were referred to the Eye Department at Gentofte Hospital. The injured eye was examined with a photo slit-lamp before and 24 hours after treatment. The size of the abrasion was recorded and calculated on a PCX computerized video system and by slit-lamp photography.

Results & conclusion: The Fucithalmic and chloramphenicol ointment treated groups showed no significant difference in corneal healing, local side effects, or signs of local infection.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / adverse effects
  • Chloramphenicol / administration & dosage*
  • Chloramphenicol / adverse effects
  • Cornea / drug effects
  • Corneal Injuries*
  • Epithelium, Corneal / drug effects
  • Eye Infections / drug therapy
  • Eye Injuries / drug therapy*
  • Female
  • Fusidic Acid / administration & dosage*
  • Fusidic Acid / adverse effects
  • Humans
  • Incidence
  • Male
  • Ointments
  • Ophthalmic Solutions
  • Single-Blind Method
  • Wound Healing / drug effects
  • Wounds, Nonpenetrating / drug therapy*


  • Anti-Bacterial Agents
  • Ointments
  • Ophthalmic Solutions
  • Fusidic Acid
  • Chloramphenicol