Abstract
Administration of IL-1 beta and 125-129 fragment of alpha 2-interferon improved learning and retention of active avoidance behaviour in memory in rats. It also improved the correlation between intersignal runs and success of the avoidance behaviour learning. The data obtained suggest that an activation of the intersignal retention process is one of the mechanisms of the immunomodulators effect on learning and memory.
MeSH terms
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Adjuvants, Immunologic / pharmacology*
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Animals
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Avoidance Learning / drug effects*
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Avoidance Learning / physiology
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Conditioning, Psychological / drug effects
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Escape Reaction / drug effects*
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Escape Reaction / physiology
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Exploratory Behavior / drug effects
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Interferon Type I / pharmacology*
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Interferon-alpha
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Interleukin-1 / pharmacology*
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Male
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Memory / physiology*
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Neuroimmunomodulation / drug effects*
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Neuroimmunomodulation / physiology
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Peptide Fragments / pharmacology*
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Rats
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Rats, Wistar
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Reaction Time / drug effects
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Recombinant Proteins
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Systems Theory
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Vocalization, Animal / drug effects
Substances
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Adjuvants, Immunologic
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Interferon Type I
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Interferon-alpha
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Interleukin-1
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Peptide Fragments
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Recombinant Proteins
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interferon, alfa 2(125-129)