Maintaining iron balance with total-dose infusion of intravenous iron dextran

ANNA J. 1998 Feb;25(1):65-8.


Recombinant human erythropoietin (rHuEPO) is an important component of anemia management in patients with chronic renal failure, however, it can lead to functional iron deficiency (FID). Patients with FID are less likely to have an optimal response to rHuEPO (Cavill et al., 1997). Intravenous (i.v.) iron dextran is often required to replace iron losses, maintain adequate iron stores, and correct iron deficiency. The following article provides a rationale for the use of IV iron dextran and details one unit's protocol and experience with its use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Iron-Deficiency / drug therapy*
  • Anemia, Iron-Deficiency / etiology*
  • Anemia, Iron-Deficiency / metabolism
  • Drug Monitoring
  • Erythropoietin / administration & dosage
  • Hematinics / administration & dosage*
  • Humans
  • Injections, Intravenous
  • Iron / metabolism*
  • Iron-Dextran Complex / administration & dosage*
  • Kidney Failure, Chronic / complications*
  • Nursing Assessment
  • Recombinant Proteins


  • Hematinics
  • Recombinant Proteins
  • Erythropoietin
  • Iron-Dextran Complex
  • Iron