Erythropoietin in amniotic fluid as a marker of chronic fetal hypoxia

Int J Gynaecol Obstet. 1998 Mar;60(3):257-63. doi: 10.1016/s0020-7292(98)00011-3.


Objective: To determinate the erythropoietin concentration in amniotic fluid in normal pregnancies and pregnancies with suspected hypoxia.

Method: The erythropoietin concentration of 164 samples of amniotic fluid was determined by ELISA. The samples were taken by amniotomy during birth, as well as amniocentesis conducted during prenatal care.

Results: A distribution of 1.07-7.29 U/l (10th-90th percentile) within the normal group (n = 106) was determined. Significantly elevated erythropoietin levels in amniotic fluid were determined in maternal hypertension (P = 0.039) and low birth-weight children (P = 0.0032). A correlation with the child's sex could be excluded.

Conclusion: Elevated erythropoietin levels in amniotic fluid indicated chronic fetal hypoxia.

MeSH terms

  • Adolescent
  • Adult
  • Amniotic Fluid / chemistry*
  • Biomarkers
  • Chronic Disease
  • Erythropoietin / analysis*
  • Female
  • Fetal Hypoxia / diagnosis*
  • Fetal Hypoxia / metabolism
  • Humans
  • Pregnancy
  • Prenatal Diagnosis / methods*
  • Risk Factors


  • Biomarkers
  • Erythropoietin