Translation control: connecting mitogens and the ribosome

Curr Biol. 1998 Mar 26;8(7):R248-50. doi: 10.1016/s0960-9822(98)70152-6.

Abstract

The identification of 3-phosphoinositide-dependent kinase 1 (PDK1) as one of the elusive 70 kDa S6 kinase kinases has filled a gap in the signaling pathway by which extracellular receptors regulate translation. Will it cause us to reconsider the relationships between previously identified members of the pathway?

Publication types

  • Review

MeSH terms

  • 3-Phosphoinositide-Dependent Protein Kinases
  • Amino Acid Sequence
  • Animals
  • Humans
  • Mitogens / pharmacology*
  • Models, Biological
  • Molecular Sequence Data
  • Protein Biosynthesis / drug effects*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases / genetics
  • Ribosomal Protein S6 Kinases / metabolism
  • Ribosomes / drug effects*
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Sequence Homology, Amino Acid
  • Signal Transduction

Substances

  • Mitogens
  • Proto-Oncogene Proteins
  • 3-Phosphoinositide-Dependent Protein Kinases
  • PDPK1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases