Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart

Mech Dev. 1998 Apr;73(1):125-7. doi: 10.1016/s0925-4773(98)00037-9.


NK-2 class homeobox genes are candidate patterning and lineage regulators in diverse organisms. We report here the embryonic expression pattern of murine member, Nkx2-6. In keeping with its vertebrate relatives, Nkx2-6 was transcribed in ventrolateral embryonic structures. Expression was first detected at E8.0 in endodermal walls of the foregut pocket, tissue destined to become pharyngeal floor. From E8.0-10.5, transcripts were concentrated in pharyngeal pouches and juxtaposed arch ectoderm and mesoderm, as well as in more caudal gut segments. Expression was also seen at opposite poles of the developing heart from E8-8.5 in posterior myocardial progenitors, then sinus venosa and dorsal pericardium, and from E9.5 in outflow tract myocardium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila Proteins
  • Endoderm / metabolism*
  • Genes, Homeobox / genetics*
  • Heart / embryology*
  • Homeodomain Proteins / biosynthesis
  • Homeodomain Proteins / genetics*
  • In Situ Hybridization
  • Intestinal Mucosa / metabolism
  • Intestines / embryology*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Transcription Factors


  • Drosophila Proteins
  • Homeodomain Proteins
  • Nkx2-6 protein, mouse
  • Transcription Factors
  • vnd protein, Drosophila

Associated data

  • GENBANK/AF045150