Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination

Nat Med. 1998 Apr;4(4):421-7. doi: 10.1038/nm0498-421.


The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell clones as opposed to infection by blood borne virus in situ. The dynamics of SIV quasispecies in peripheral blood suggests sequential waves of viral replication, illustrating the role of antigenic stimulation as a driving force in viral dissemination and pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • BCG Vaccine / pharmacology*
  • Base Sequence
  • DNA Primers
  • Eyelids
  • Gene Products, env / chemistry
  • Gene Products, env / genetics*
  • Gene Rearrangement, T-Lymphocyte
  • Genetic Variation
  • Hypersensitivity, Delayed*
  • Macaca mulatta
  • Molecular Sequence Data
  • Mycobacterium tuberculosis / immunology
  • Phylogeny
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Receptor-CD3 Complex, Antigen, T-Cell / genetics
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Immunodeficiency Virus / drug effects
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / physiology*
  • T-Lymphocytes / immunology*
  • Virus Replication / drug effects
  • Virus Replication / immunology*


  • BCG Vaccine
  • DNA Primers
  • Gene Products, env
  • Receptor-CD3 Complex, Antigen, T-Cell