Opioid dependence during pregnancy. Effects and management

Obstet Gynecol Clin North Am. 1998 Mar;25(1):139-51. doi: 10.1016/s0889-8545(05)70362-4.


This article describes the complex problems associated with opioid dependence during pregnancy. Medical, obstetric, and psychosocial problems are presented. Methadone maintenance for the treatment of opioid dependence is described in this article. Specific issues of appropriate methadone dose during pregnancy, medical withdrawal, and the relationship of methadone dose and the severity of neonatal abstinence also are discussed.

Publication types

  • Review

MeSH terms

  • Delivery, Obstetric
  • Female
  • Humans
  • Infant, Newborn
  • Methadone / pharmacology
  • Methadone / therapeutic use
  • Narcotics / adverse effects
  • Neonatal Abstinence Syndrome / physiopathology
  • Neonatal Abstinence Syndrome / prevention & control
  • Opioid-Related Disorders* / complications
  • Opioid-Related Disorders* / drug therapy
  • Postnatal Care
  • Pregnancy
  • Pregnancy Complications* / chemically induced
  • Pregnancy Complications* / drug therapy
  • Pregnancy Complications* / psychology


  • Narcotics
  • Methadone