Angiogenesis in rheumatoid arthritis: pathogenic and clinical significance

J Investig Med. 1998 Feb;46(2):27-41.


In summary, angiogenesis, the formation of new blood vessels, is important in leukocyte extravasation and thus the pathogenesis of RA. The outcome of neovascularization highly depends on the imbalance between angiogenic and angiostatic mediators produced in the rheumatoid synovium. Therefore, angiogenesis research is important for the understanding of the pathogenesis of inflammatory arthritis. In addition, existing and potential angiostatic drugs may be useful for future therapy of RA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / pathology*
  • Arthritis, Rheumatoid / physiopathology
  • Cell Adhesion Molecules / physiology
  • Chemokines / physiology
  • Cytokines / physiology
  • Extracellular Matrix / physiology
  • Growth Substances / physiology
  • Humans
  • Models, Biological
  • Neovascularization, Pathologic* / drug therapy
  • Neovascularization, Pathologic* / physiopathology


  • Cell Adhesion Molecules
  • Chemokines
  • Cytokines
  • Growth Substances