Abstract
Using classical microelectrode techniques in canine cardiac Purkinje fibres, calcium ionophore X-537A was shown to shorten the action potential, hyperpolarizing the membrane and lowering the plateau, suggesting that intracellular calcium controls membrane permeability to potassium in this preparation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Action Potentials / drug effects
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Animals
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Anti-Bacterial Agents / pharmacology*
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Dogs
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Heart Conduction System / drug effects*
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In Vitro Techniques
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Lasalocid / pharmacology*
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Membrane Potentials / drug effects
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Practolol / pharmacology
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Purkinje Fibers / drug effects*
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Purkinje Fibers / physiology
Substances
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Anti-Bacterial Agents
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Practolol
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Lasalocid