The electrophysiological effects of ionophore X-537A on cardiac purkinje fibres

Experientia. 1976;32(7):906-7. doi: 10.1007/BF02003760.

Abstract

Using classical microelectrode techniques in canine cardiac Purkinje fibres, calcium ionophore X-537A was shown to shorten the action potential, hyperpolarizing the membrane and lowering the plateau, suggesting that intracellular calcium controls membrane permeability to potassium in this preparation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Dogs
  • Heart Conduction System / drug effects*
  • In Vitro Techniques
  • Lasalocid / pharmacology*
  • Membrane Potentials / drug effects
  • Practolol / pharmacology
  • Purkinje Fibers / drug effects*
  • Purkinje Fibers / physiology

Substances

  • Anti-Bacterial Agents
  • Practolol
  • Lasalocid