[Acute perceptive hearing loss and metabolic acidosis as complications of the topical treatment of psoriasis with salicylic acid-containing ointment]

Ned Tijdschr Geneeskd. 1997 Oct 25;141(43):2075-9.
[Article in Dutch]


A 36-year-old woman, hospitalized because of an exacerbation of psoriasis, developed fever, sudden deafness and severe metabolic acidosis after treatment with a 10% salicylic acid containing ointment for four days. The use of salicylic acid on large areas of inflamed skin enhances the risk of transcutaneous resorption and intoxication. High serum concentrations (> 300 mg/l) of salicylic acid deregulate the blood glucose metabolism and cause damage to the inner ear. After timely intervention such symptoms are largely reversible.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Disease
  • Adult
  • Female
  • Hearing Loss, Sensorineural / chemically induced*
  • Humans
  • Keratolytic Agents / administration & dosage
  • Keratolytic Agents / adverse effects*
  • Keratolytic Agents / metabolism
  • Ointments
  • Psoriasis / drug therapy*
  • Salicylates / administration & dosage
  • Salicylates / adverse effects*
  • Salicylates / metabolism


  • Keratolytic Agents
  • Ointments
  • Salicylates